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According to the Associated Press, U.S. Vice President Vance has canceled his trip to Pakistan.

According to Odaily Planet Daily, the Iranian negotiating team announced to the US through Pakistani intermediaries that, for various reasons, they will not travel to Islamabad, Pakistan on the 22nd and currently have no possibility of participating in the negotiations. Sources indicate that after Pakistan intervened to mediate and requested a ceasefire from the US, Iran accepted the ceasefire agreement and agreed to conduct subsequent negotiations to end the war based on a ten-point framework it proposed, which had already been accepted by the US. Pakistan also explicitly stated that the US accepted this framework. However, in the days that followed, the US began to renege on its promises. Furthermore, in the first round of negotiations held in Islamabad, the US made many excessive demands, effectively violating the initial framework, leading to a stalemate in that round of talks. Sources also stated that in the exchanges over the past few days, the US insisted on its excessive demands, which infringe upon the absolute rights of the Iranian people, and the exchanges between the two sides have not made any substantial progress. Therefore, Iran finally announced today that, under these circumstances, participating in the negotiations would be a waste of time, as the US is preventing any substantive agreement from being reached.

According to Odaily Planet Daily, on the afternoon of April 21st local time, US President Trump posted on "Real Social Media" that, at the request of the Pakistani Army Chief of Staff and Prime Minister, the US will temporarily suspend military strikes against Iran, extend the ceasefire, and require Iran to first submit a unified negotiation proposal. During this period, the US military will continue to maintain a naval blockade against Iran while remaining on a state of military readiness. He stated that the ceasefire will continue until Iran submits a proposal and completes negotiations, "regardless of the outcome."